Human osteosarcoma-derived soluble bone morphogenetic protein
Bauer, F.C.; Urist, M.R.
Clinical Orthopaedics and Related Research 154: 291-295
1981
ISSN/ISBN: 0009-921X PMID: 6937275 Document Number: 178281
A bone morphogenetic protein (BMP) fraction obtained from the organic matrix of dentin is extractable from human osteosarcoma. A fresh en-bloc specimen excised from the femur of a 16-year-old boy was extracted with 4 M guanidine hydrochloride. The GuHCl-soluble, water-insoluble protein fraction induced new bone formation when implanted into the thigh muscles of athymic nude mice.
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