New chemotherapeutic nitroheterocycles active against 5-nitroimidazole-resistant strains of trichomonads
Meingassner, J.G.; Nesvadba, H.; Mieth, H.
Arzneimittel-Forschung 31(1): 6-8
1981
ISSN/ISBN: 0004-4172 PMID: 6971111 Document Number: 177896
The synthesis and the trichomonacidal activity of some 4-substituted 2-imidazolylquinazoline derivatives are described. The new compounds were highly active against metronidazole-sensitive and metronidazole-resistant strains of trichomonads. This was demonstrated in vitro as well as in various trichomoniasis models in mice and rats after oral treatment.