The role of T3 and its receptor in efficient metabolisers receiving very-low-calorie diets
Moore, R.; Mehrishi, J.N.; Verdoorn, C.; Mills, I.H.
International Journal of Obesity 5(3): 283-286
1981
ISSN/ISBN: 0307-0565 PMID: 6268557 Document Number: 177653
Obese patients taking a 1.34-MJ formula diet daily showed a steady decline in rate of weight loss after several weeks, associated with a decrease in resting metabolic rate, serum triiodothyronine (T3) and the number of T3 receptors on peripheral lymphocytes. The addition of T3, 60 mu g daily, to the diet produced a significantly greater weight loss by the 12th week. Analysis of individual thyroid hormone values showed that patients taking the T3 tablets who achieved the greatest weight loss had the lowest serum T3 values but the greatest suppression of serum thyroxine. The serum T3 values in the T3-treated subjects were negatively correlated with the lymphocyte receptor capacity.