Effects of manganese deficiency in presence of excess cobalt and vice versa on serum lipoprotein profiles of rats receiving normal and atherogenic diets
Mallik, A.K.
Indian Journal of Biochemistry and Biophysics 22(4): 226-231
1985
ISSN/ISBN: 0301-1208 PMID: 3833659 Document Number: 248689
The incidence of experimental atherosclerosis using an atherogenic diet vis-a-vis the control of hyperlipidemia and hyperlipoproteinemia has been suggested in albino rats due to interactions of mineral salts (cobalt chloride and manganous sulphate, for example) administered to the animals. An adequate oral substitution of cobalt or intravenous administration of a low dose of managanese to animals surviving on salt-free normal diet, helps to produce hyperlipidemic changes including enhance C/P ratio in serum, and an increase in total LP-protein concentrations. A major share of increase in serum cholestersol and neutral fats is once again reflected in the significant rise of these 2 components in .beta.-LP fraction over the control animals. It also suggests a shift of serum cholesterol pool from .alpha.1 to .beta. fraction of the major LP classes. On the other hand, animals necessarily fed with salt-free atherogenic diet regimen, when exposed to a deficient cobalt therapy or enriched with manganese supplements, experience a lowering of hyperlipidemia with concomitant decrease in C/P ratio. A sharp reduction in serum triglyceride and protein levels is also noticed in this case.