Immune complex-dependent T cell-mediated cytostasis (IDTC)
Tanaka, J.; Yata, J.
Clinical and Experimental Immunology 45(1): 215-223
1981
ISSN/ISBN: 0009-9104 PMID: 6975682 Document Number: 177531
The growth of human lymphoid cell lines [Burkitt's lymphoma Raji and Daudi cells] was suppressed by human peripheral T cells in the presence of immune complexes (IC). T cells bearing IgG receptors (Tg cells) were, but T-non-G cells and non-T cells were not, active as effectors of cytostasis which was induced by IC-mediated bridging of the target and effector cells via Fc receptors. This phenomenon was called immune complex-dependent T cell-mediated cytostasis (IDTC ) was suggested. TG cells from healthy individuals suppressed Ig production and were cytotoxic effectors upon interaction with IC. The cytotoxic effectors seem to be distinct from the suppressors of Ig production since TG cells from rheumatoid arthritis patients showed dissociation between these 2 functions; they displayed cytostasis but had only little suppressive effect on the B cell response.