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Regulation of genetic activity by thyroid hormones. II. Specificity of interaction of cytoplasmic thyroxine receptor isolated from human embryonal fibroblasts and Hela cells with DNA

Abdukarimov, A.; Guliamova, T.G.; Aripdzhanov, A.A.; Khan, M.Z.

Problemy Endokrinologii 27(2): 66-70

1981

ISSN/ISBN: 0375-9660
PMID: 6262749
Document Number: 176662
The work concerns a new approach to evaluating the receptor and hormone-receptor complex specific interaction with DNA and revealing the cause of the absence of the hormone-receptor complex acceptation with HeLa cell chromosomes. It has been shown that hormone-receptor complexing should precede specific interaction with DNA. The purified receptor-thyroxin complex is saturatable and specifically competes with Hae III restrictase, protecting specific sites of DNA recognition from this enzyme. Specificity of the hormone-receptor complex interaction with DNA depends on the sequences surrounding Hae III restriction site. The HeLa cell hormone-receptor complex does not interact with the recognition site for the normal hormone-receptor complex.

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