The regulation of DNA repair processes in mammalian cells. III. The effect of epidermal growth factor on the postradiation recovery of the cell cycle in human A 431 cells and embryonic fibroblasts
Kirillova, T.V.; Seregina, T.B.; Bil'din, V.N.
Tsitologiia 34(5): 94-104
1992
ISSN/ISBN: 0041-3771 PMID: 1455555 Document Number: 393614
Recovery of the cell cycle in cells A 431 and in human embryo fibroblasts (EFH) differs much. Unlike EFH, A 431 cells have: 1) synchronized exit of cells from G1 into S phase after 5 Gr irradiation; 2) G2-block; 3) much less manifestation of these two phenomena in the presence of EGF; 4) a lesser effectiveness of the repair of DNA single-strand breaks. EGF stimulation of the repair of radiation-induced DNA lesions, SSB in particular, may be of great importance for the postirradiation cell cycle recovery.