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Cell cycle regulation in mammalian cells: hormones and commitment to DNA synthesis

Armelin, H.A.; Armelin, M.C.

Archivos de Biologia y Medicina Experimentales 12(3): 319-324

1979

ISSN/ISBN: 0004-0533
PMID: 399721
Document Number: 144190
The growth regulation of cultured mouse fibroblasts and functional adrenal cells was studied. Variants of mutants from these cell lines were obtained. The effects of classical hormones (insulin, hydrocortisone and adrenocorticotropin) and of growth factors (EGF and PF) were analysed. These hormones stimulate or inhibit the entry of cells into S phase. However G1 cells become irreversibly committed to DNA synthesis 5 hours before entering S phase.

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