The efficacy of gestoden (delta 15-d-norgestrel) as ovulation inhibitor
Schneider, W.H.; Schmid, R.; Spona, J.
Wiener Klinische Wochenschrift 93(19): 601-604
1981
ISSN/ISBN: 0043-5325 PMID: 6798765 Document Number: 175986
2 single-phase combined low dose oral contraceptives (OCs) were tested with respect to their effects on functional parameters of the menstrual cycle. 20 young women with a normal biphasic menstrual cycle took part in this randomized study. Evaluation of cervical function, consistency, and crystallization ability of the cervical mucus and of the karyopyknosis index, as well as radioimmunoassay of the serum levels of LH, FSH, HPRL, 17beta-estradiol, and progesterone were carried out consecutively as from the 8th day over the duration of 1 control cycle and 1 in which OCs were administered. Preparation 1 (SH D 356 A) contained 75 mcg delta 5-d-norgestrel (Gestoden)+30 mcg ethinyl estradiol. Preparation 2 (SH D 356B) contained 75 mcg d-norgestrel+30 mcg ethinyl estradiol. Both substances successfully inhibited ovulation, whereby the former achieved a markedly greater suppression of function with regard to all parameters and, yet good menstrual cycle control was maintained. Hence, Gestoden enables the content of active components in OCs to be reduced even further without detracting from the safety of the method. (author's)