Characteristics of the mutagenic action of 1,4-bis-diazoacetylbutane on mature Drosophila melanogaster sperm
Aslanian, M.M.; Kim, A.I.; Smirnova, V.A.
Genetika 17(4): 677-683
1981
ISSN/ISBN: 0016-6758 PMID: 6785154 Document Number: 175814
The mutagenic action of 1,4-bis-diazoacetylbutane was studied. No dominant lethals induced by this mutagen were detected. Up to 3.61% recessive lethal mutations were observed by the Muller-5 test. Visible mutations were detected, the majority of them having been obtained in the second generation. Four visible mutations from 11 observed concerned the eye shape and belonged to the same locus "Lobe" and 3 mutations--to the "chocolate" one. This effect might be due to the loci-specific action of the 1,4-bis-diazoacetylbutane. Three cases of replicating instability, with the stabilization of either mutant or normal state of the gene were registered. Strong morphogenic action of this mutagen has been revealed.