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A mutant strain of Drosophila simulans sensitive to the toxic and mutagenic action of benz (a) pyrene

Fuks, S.I.; Safaev, R.D.; Khovanova, E.M.; Ugnivenko, E.G.; Belitskiĭ, G.A.

Voprosy Onkologii 37(9-10): 948-953

1991

ISSN/ISBN: 0507-3758
PMID: 1842655
Document Number: 384965
A 364 yv strain sensitive to the toxic effect of benzo(a)pyrene (BP) was identified among 49 mutant strains of Drosophila simulans. Heterozygotes female 364 x male Turku obtained by crossing 364 yv species with those of wild BP-resistant Turku strain were more sensitive than female Turku x male 364 heterozygotes to both toxic and mutagenic effects of the carcinogen in the test of induction of somatic mosaicism with the yellow marker. Non-carcinogenic pyrene appeared weekly toxic and non-mutagenic. Possible mechanisms of 364 yv strain sensitivity to BP as well as vistas in application of the strain for monitoring genotoxic environmental pollution are discussed.

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