Specific mutagenic effectiveness of 1,4-bis-diazoacetylbutane in relation to individual genes
Vasil'eva, S.V.; Rapoport, I.A.
Genetika 13(1): 132-137
1977
ISSN/ISBN: 0016-6758 PMID: 348566 Document Number: 114651
A selective effect of 1,4-bis-diazoacetylbutane (DAB) with respect to individual genes is observed when studying its mutagenic action on bacterial strains. Escherichia coli and Salmonella typhimurium. The frequency of mutations to thr+ exceeded in three orders the background of spontaneous variability for this marker. No induced mutations to trp+ and his+ leu+, which might be the result of transition, transversions, suppressor mutations and frame shift mutations, were detected. Mutagenic effect of DAB is due to the functioning of the gene uvr+. Several hypotheses are proposed on possible mechanism of the specific effect of DAB with respect to individual genes.