Fronto-hippocampal activity during the organization of feeding behavior in rats with bilateral destruction of the lateral hypothalamus
Zilov, V.G.; Rogacheva, S.K.
Biulleten' Eksperimental'noi Biologii i Meditsiny 92(9): 292-294
1981
ISSN/ISBN: 0365-9615 PMID: 7295985 Document Number: 175688
The recovered feeding behavior and effects of electrical stimulation of the dorsal hippocampus (HIP) and frontal cortex (FC) on different stages of feeding behavior were studied in rabbits after bilateral lesions of the lateral hypothalamus (LH). Severe damages to food motivation were recorded, which were primarily manifested by the absence of active search for food by hungry animals. Electrical stimulation of HIP and FC inhibited feeding behavior. This was shown by the increased latent period of feeding behavior and by the arrest of the already developed food reaction. The preservation of fronto-hippocampal inhibition after intravenous injection of droperidol (0.3 mg/kg) and atropine (1 mg/kg) seen in experimental animals (comparatively to intact ones) indicates that in rabbits with bilateral LH lesions the feeding behavior is realized by the new integration of cholinergic and dopaminergic brain structures.