Effect of ethosuximide on dopaminergically mediated behaviours

Jadhav, J.H.; Balsara, J.J.; Jeurkar, A.J.; Chandorkar, A.G.; Jadhav, J.H; Balsara, J.J; Jeurkar, A.J; Chandorkar, A.G

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Effect of ethosuximide on dopaminergically mediated behaviours

Jadhav, J.H.; Balsara, J.J.; Jeurkar, A.J.; Chandorkar, A.G.

Indian Journal of Physiology and Pharmacology 25(3): 274-278

1981

ISSN/ISBN: 0019-5499

PMID: 7197666

Document Number: 175648

Pretreatment with ethosuximide, a drug of choice for petit mal epilepsy, inhibited the conditioned avoidance response in rats and the traction response in mice and antagonized methamphetamine-induced stereotyped behavior in rats. The results, which indicate that ethosuximide is capable of inhibiting the dopaminergically mediated behaviors, are in agreement with the recent reports stating that ethosuximide exerts central dopamine receptor blocking activity.