Improved isocratic liquid-chromatographic simultaneous measurement of phenytoin, phenobarbital, primidone, carbamazepine, ethosuximide, and N-desmethylmethsuximide in serum
Szabo, G.K.; Browne, T.R.
Clinical Chemistry 28(1): 100-104
1982
ISSN/ISBN: 0009-9147 PMID: 6895720 Document Number: 188108
An improved high-pressure liquid-chromatographic assay for simultaneous determination in ranged from 1.6-5.4%, and between-day CV from 0.0-3.4% in subtherapeutic, therapeutic and toxic samples. Resolution of therapeutic concentrations of all 6 drugs was complete. As yet, no drug or drug metabolite that interferes was found.
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