Probable pseudocholinesterase induction by valproic acid, carbamazepine and phenytoin leading to increased serum aspirin-esterase activity in epileptics
Puche, E.; Garcia Morillas, M.; Garcia de la Serrana, H.; Mota, C.
International Journal of Clinical Pharmacology Research 9(5): 309-311
1989
ISSN/ISBN: 0251-1649 PMID: 2516508 Document Number: 337049
The present findings show clearly that valproic acid, carbamazepine and phenytoin are each capable of significantly raising serum aspirin-esterase activity in epileptics being treated with these drugs (between p less than 0.01 and p less than 0.05). The data suggest that these antiepileptic drugs may well act as enzymatic-inducing agents upon plasma cholinesterase (or pseudocholinesterase) in epileptic patients.