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Role of the mesencephalon reticular formation in the effect of ethosuximide on a cortical epileptogenic focus

Kästner, I.; Mestwirischwili, L.P.; Bagaschwili, T.U.

Acta Biologica et Medica Germanica 39(4): 455-459

1980

ISSN/ISBN: 0001-5318
PMID: 7445895
Document Number: 155711
Ethosuximide provoked in encéphale isolé cats a dose-dependent suppression or facilitation of strychnine focus spiking activity, and in combination with high frequency stimulation of formatio reticularis mesencephali a significant activation of the cortical focus. The results seem to show that the influence of ethosuximide on the formatio reticularis mesencephali is one--if not the main--component of the drug effect.

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