Amoxicillin preparation with prolonged activity
Kochi, T.; Honda, T.; Itoh, N.; Yogo, M.; Yamaguchi, H.
Japanese Journal of Antibiotics 34(11): 1470-1476
1981
ISSN/ISBN: 0368-2781 PMID: 7334581 Document Number: 174884
This study was performed to develop a prolonged acting preparation on the bases of our in vitro study of AMPC that the bacterial effects of AMPC were not proportional to the concentration of and above MIC but to the exposing time. A desirable serum level was obtained in the AMPC preparation containing 30% of non-coated granules and 70% of enteric-coated granules dissolvable on and above pH 6. The duration time of the serum concentration on and above 2.5 micrograms/ml in the administration of this preparation (500 mg (Potency)) was 5.3 hours and it was 2.4 times that of the conventional capsule (250 mg (Potency)). The prolonged activity of this preparation was also observed in the urinary concentration. These results suggest that this prolonged action granules of AMPC could reduce the administration frequency and also might be more useful in increasing therapeutic effects than conventional capsule.