Is the human trophoblast in vitro an adaptive tissue for immunological influences?
Kolesnikov, S.I.; Trunova, L.A.; Ignatovich, N.V.; Paraskun, V.G.
Acta Biologica Academiae Scientiarum Hungaricae 32(2): 147-156
1981
ISSN/ISBN: 0001-5288 PMID: 6800169 Document Number: 173083
The role of the extra-embryonic organs (e.g. placenta) in the feto-maternal immunological interactions is not clear. Trophoblast cells of human placenta were studied in vitro in relation to their adaptive capacities under the immunological influence of allogeneic leucocytes of pregnant women. It was shown that after an 18-h interaction some trophoblastic cells were still viable, they were rich in glycoproteins and RNA, and elicited a prominent activity of some enzymes. Mitosis was often seen. The authors suppose that the trophoblast is highly adaptable to some immunological influences in vitro.