Adaptive Remodelling of Bone Tissue in Total Hip Replacement
Karyakina, E.V.; Gladkova, E.V.; Persova, E.A.; Puchin'yan, D.M.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 102(3): 351-361
2016
ISSN/ISBN: 0869-8139 PMID: 30188669 Document Number: 691161
Instrumental and laboratory monitoring of bone tissue adaptive remodeling processes after total hip replacement conducted for primary osteoarthrosis patients (32 males and 48 females) (coxarthrosis stage III, functional insufficiency stages II and III) with long-lasting joint damage, significant pain syndrome and osteodeficit, indicated osteodeficit intensification compared to the baseline in the implant surrounding areas. These patients showed an increasing cytokine imbalance in the blood serum postsurgically with the primary activation of proinflammatory (osteoresorbing) element and secondary activation of anti-inflammatory element. Structural and functional characteristics of bone tissue in the area adjacent to the implant and cytokine balance indexes in the blood serum did not return to the baseline even 12-15 months postsurgically.