The influence of autologous erythrocytes on active T-cells rosetting with sheep red blood cells and on DNA synthesis
Nowaczyk, M.; Skopińska-Rózewska, E.
Archivum Immunologiae et Therapiae Experimentalis 29(3): 391-396
1981
ISSN/ISBN: 0004-069X PMID: 6975089 Document Number: 168988
The addition of autologous erythrocytes to a mixture of human peripheral blood lymphocytes and sheep red blood cells alters the spontaneous rosetting reaction in the test detecting the active fraction of T lymphocytes. Increase in rosetting was more often observed in mixtures containing smaller human red blood cell:lymphocyte ratios while inhibition occurred in those containing a higher ratio. Autologous erythrocytes also affected DNA synthesis when added to 3 day old lymphocyte cultures, stimulated or unstimulated with BCG. These effects were more strongly pronounced when phagocytic cells were removed from the tested lymphocytes.