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Joint action of aminoglycoside antibiotics and nitrofurans with bile on bacteria of the genus Proteus

Sytnik, I.A.; Puzakova, E.V.

Antibiotiki 25(6): 437-440

1980

ISSN/ISBN: 0003-5637
PMID: 7396441
Document Number: 165920
The combined effect of monomycin, kanamycin, neomycin and nitrofurans, such as furacillin, furagin, nitrofurantoin and furazolidone with bovine bile was studied on 36 strains of Proteus mirabilis and 14 strains of Proteus vulgaris. It was found that sub-bacteriostatic doses of the bile significantly increased the antiproteus activity of the aminoglycoside antibiotics and nitrofurans. The combinations of the bile with monomycin and kanamycin and the bile with furazolidone and nitrofurantoin proved to be most effective. Clinical trials of the drugs in treatment of inflammatory diseases of the biliferous system of the Proteus etiology are recommended.

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