Effect of maternal administration of papain on rat foetal liver and kidney
Singh, S.; Devi, S.
Indian Journal of Medical Research 72: 300-307
1980
ISSN/ISBN: 0019-5340 PMID: 7228167 Document Number: 165812
Livers and kidneys obtained from 20 day old rat fetuses, whose mothers were given crude papain orally or i.p. in single or repeated doses during gestation days 8-17 (sperm+ = day 0), were examined and processed for histological study. Gross examination of the livers showed dark patchy areas with hemorrhages, which were confirmed histologically. Liver cytoarchitecture was lost. Degenerating liver cords revealed loss of basophilia and poor PAS [periodic acid-Schiff] stained material. Sinusoids were dilated showing empty spaces. Besides focal hemorrhages, central veins were dilated, congested and showed rupture of endothelial lining. The kidneys were markedly enlarged in treated cases and showed subcapsular and deeper hemorrhages. Glomeruli were atrophic and shrunken. The tubules showed marked degeneration with dilated empty spaces.