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Lysis of rat liver lysosomes through incubation with 1-leucyl-glycine, substrate for a lysosomal dipeptidase

Zuretti, M.F.; Bouma, J.M.; Barrera, G.; Messina, M.; Baccino, F.M.

Bollettino della Societa Italiana di Biologia Sperimentale 56(6): 610-614

1980

ISSN/ISBN: 0037-8771
PMID: 7378195
Document Number: 165746
L-Leu-Gly is a substrate for a lysosomal dipeptidase. The incubation of subcellular fractions in the presence of the dipeptide causes rapid lysis of the particles, as revealed by the increase of free and soluble activities of acid phosphatase. This effect is due to the hydrolysis of the dipeptide within the particles, as documented by the concomitant aminoacid production. The enhancing effect of EDTA on this phenomenon is reported.

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