Effect of mellaril on the liver lysosomes of rats with acute toxic hepatitis
Korolenko, T.A.; Tsilli, E.I.; Rusova, T.V.
Farmakologiia i Toksikologiia 39(4): 467-470
1976
ISSN/ISBN: 0014-8318 PMID: 1027573 Document Number: 108443
In 24 hours after a single administration of melleril (30 mg/kg) an elevated injuriousness of "heavy" and "light" liver lysosomes of rats subjected to "in vitro" treatment with a pH 5.0 solution at 37 degrees was recorded. Introduction of melleril to rats with toxic CCl4-induced hepatitis (CCl4 dosage of 0.15 ml per 100 g body weight) depresses free activity of acid phosphatase, this fall, however, failing to reach the corresponding values in intact animals. An elevated injuriousness of "heavy" and "light" lysosomas undergoing treatment at pH 5.0 and 37degrees, revealed in all variants of the tests, is related to activation of lysosomal phospholipases with subsequent liberation of surfactant lipids and volumetric changes of the particles.