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Effect of choriogonine on the enzymatic activity of lysosomes in the cirrhotic liver in the rat

Blinova, T.V.; Solopaeva, I.M.; Zharikova, G.V.

Voprosy Meditsinskoi Khimii 28(6): 41-45

1982

ISSN/ISBN: 0042-8809
PMID: 6818764
Document Number: 195706
Liver tissue cirrhosis, developed in rats after long-term administration of CCl4, led to distinct increase in activities of acid phosphatase, acid DNAase, cathepsin D, beta-galactosidase and beta-glucosidase. When the treatment with the hepatotropic toxins was stopped activity of lysosomal enzymes decreased slightly but was maintained at the high level. Within a day after a single administration of choriogonine distinct decrease as compared with the controls in activity of all the acid hydrolases studied was found. Within subsequent periods the lysosomal enzymes activity continued to decrease and within 2 months after the choriogonine treatment it was distinctly lower as compared with control animals.

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