Change in the enzymatic activity of liver carbohydrate metabolism after the one-time carbon tertrachloride poisoning of rats
Sorokin, A.S.; Iakobson, G.S.
Voprosy Meditsinskoi Khimii 25(4): 433-435
1979
ISSN/ISBN: 0042-8809 PMID: 473683 Document Number: 148332
Activity of gluconeogenesic enzymes was more distinctly decreased than the activity of glycolytic enzymes within 8 and 24 hrs after a single intoxication of rats with CCl4. Within 72 hrs the enzymatic activity of glycolysis and gluconeogenesis was similar but the activity of the enzymes participating in the hexose monophosphate shunt was 2-3-fold higher as compared with the patterns characteristic for the intact animals. Mechanisms of these alterations are discussed; they are apparently related to the change in hepatocyte population due to necrosis and regeneration as well as to localization of enzymes of gluconeogenesis in central part of liver lobule.