Comparative study of the estrogenic, antifertility and antigonadotropic effects of modified estrogens
Ivanenko, T.I.; Fedotov, V.P.; Strecke, J.; Ottel, M.
Problemy Endokrinologii 26(6): 67-74
1980
ISSN/ISBN: 0375-9660 PMID: 7454714 Document Number: 165166
Estrogen (in uterotropic test on sexually immature female rats), antifertile (in experiments on sexually mature pregnant female rats), and antigonadotropic (in a test on sexually immature male rats) properties of some 2- and 4-bromine and silylsubstituted estradiols were compared in oral administration. 4-silylestradiols expressed marked antigonadotropic effects equal by activity to mestranol standard, and reduced as compared with the standard antifertile and estrogenic properties. 2- and 4-bromide and 2-silylestradiols were weakly active or inactive oral estrogens and possessed no antifertile properties.