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Effects of estrogenic hormones on uteroplacental hemodynamics and progesterone production in the sheep

Assali, N.S.; Clark, K.E.; Zugaib, M.; Brinkman, C.R.; Nuwayhid, B.

International Journal of Fertility 23(3): 219-223

1978

ISSN/ISBN: 0020-725X
PMID: 40897
Document Number: 134415
Effects of diethylstilbestrol and 17-.beta.-estradiol are compared in pregnant and nonpregnant, renal hypertensive and normotensive sheep on the basis of progesterone production. Uterine blood flow is found to increase with intra-arterial administration of both hormones, but most notably in hypertensive and pregnant subjects. Progesterone production, measured by radioimmunoassay, shows a marked increase after initial administration and then assumes a pulsatile pattern.

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