Comparative studies of the estrogenic potency of mestranol and stilbestrol
Teter, J.; Krzywdziński, K.
Ginekologia Polska 42(3): 351-358
1971
ISSN/ISBN: 0017-0011 PMID: 5554647 Document Number: 40495
90 women with absent or deficient estrogenic activity were administered by means of normal substitution therapy in a routine 10-day cycle mestranol in doses of .02, .05, and .1 mg, and stilbestrol in doses of 1.0 and 2.0 mg. Estrogen potency was measured through changes in the vaginal epithelium. Cytohormonal vaginal smears were taken before and after therapy; evaluation was made on the basis of maturation index, superficial cells index, and maturation value. With the value of ''100'' given to the estrogenic activity of 1 mg of stilbestrol, with an identical effect observed with .5 mg of mestranol, a value of ''180.3'' was given for .1 mg of mestranol, and ''163'' for 2.0 mg of stilbestrol. The dose of .02 mg of stilbestrol showed the lowest value of ''34.7.''