Transcortin as an indicator of estrogenic potency in oral contraceptives
Carol, W.; Börner, A.; Klinger, G.; Greinke, C.
Endokrinologie 75(2): 167-172
1980
ISSN/ISBN: 0013-7251 PMID: 6156820 Document Number: 448750
Serum cortisol-binding globulin (CBG) was measured before, during and following a 21-day application period of 5 oral contraceptives [Ovosiston, Non-Ovlon, Gravistat, Sequenz-Ovosiston and Deposiston] used in East Germany. In a 2nd group of patients determinations were carried out at the end of a 24-mo. treatment period and the end of the 1st post-treatment cycle. From a 3rd group of volunteers blood samples were taken at the end of the 1st, 2nd and 3rd treatment cycles. All the drugs tested produced a marked CBG increase in serum, which reached its maximum at the end of the 2nd treatment cycle. Within 4 wk following termination of application the level fell to the control range. There were no significant differences between the various contraceptives.