Properties of hypolipidemic peroxisome proliferators in the lymphocyte [3H]thymidine and Salmonella mutagenesis assays
Warren, J.R.; Simmon, V.F.; Reddy, J.K.
Cancer Research 40(1): 36-41
1980
ISSN/ISBN: 0008-5472 PMID: 6765917 Document Number: 162416
Several hypolipidemic peroxisome proliferators have demonstrated carcinogenic activity in rodent species. Six of these hypolipidemic drugs were examined for their ability to induce damage in cellular DNA. Damage to DNA was evaluated by alteration in rates of thymidine and the Salmonella mutagenesis assays therefore suggest that the hypolipidemic drugs in the absence or presence of liver microsomes do not interact with and damage cellular DNA. Whether mutagenic metabolites are generated by hypolipidemic drug-induced liver peroxisomes remains to be elucidated.