Principles of the interaction of curare-like agents with skeletal muscle cholinoreceptors
Kharkevich, D.A.; Skoldinov, A.P.
Farmakologiia i Toksikologiia 43(4): 325-334
1980
ISSN/ISBN: 0014-8318 PMID: 6449373 Document Number: 161389
The principles of interaction of curare-like agents with acetylcholine receptors of skeletal muscles are discussed. The possible types of interatomic bonds of substances with receptors are exemplified by different chemical compounds which possess the neuromuscular blocking action. Prior attention is given to the role of hydrophobic interactions in the activity and mechanism of action of curare-like agents.
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