Use of parameters of ionic permeability and mechanical activity for the rating of interaction of acetylcholine with the smooth muscle M-cholinoreceptors
Komissarov, I.V.; Samoilovich, I.M.; Shovtuta, V.I.
Farmakologiia i Toksikologiia 39(4): 417-420
1976
ISSN/ISBN: 0014-8318 PMID: 1027567 Document Number: 103366
When employed in high concentrations (1-10(-5)-1-10(-3) g/ml) acetylcholine (ACC) causes an accrued uptake of Na22 and liberation of Rb86 (K) from smooth muscles of the rat's stomach. An increased release of Ca45 occurs in concentrations of 1-10(-7) g/ml and higher. The contractile reaction is recorded under the action of lower ACC concentrations (starting from 1-10(-9) g/ml). The observed changes in the ionic permeability and tonicity are due to the ACC action on the M-cholinoreceptors of the muscles. A comparison of emipirical relation between the effects and the concentration against the theoretical one showed that it is only the incorporation of Na22, liberation of Rb86 pand the contractile reaction in a depolarizing solution that adequately reflect the ACC interaction with cholinoreceptors of the smooth muscles in the rat's stomach.