Immunological aspects of ulcerative colitis. Treatment with disodium cromoglycate
Cavallini, L.; Marchi, S.; Spisni, L.; Li Calzi, M.
Archivio Per le Scienze Mediche 137(1): 13-22
1980
ISSN/ISBN: 0004-0312 PMID: 6779781 Document Number: 160993
The various components of the normal intestinal immunological system have been examined, i.e. immunocompetent cells (isolated and in clusters) and humoral factors. The modifications observed in this system during ulcerous colitis are then analysed, mention being made of the various pathogenetic interpretations that have been put forward to explain this condition. The pharmacology and action mechanism of DSCG are then examined. This drug has been in use for some years in the treatment of a number of extraintestinal and immuno-allergic based conditions and, recently, of some enteropathis attributed to food allergies. The reported results of using DSCG in ulcerous colitis are then reviewed. They would appear to be fairly encouraging.