Changes in serum gastrin, amylase, insulin and glucagon during and after open surgery with cardiopulmonary bypass
Teramoto, T.; Fukukei, I.; Okamura, E.; Kurahashi, H.; Hattori, Y.; Isaji, H.; Sai, S.; Kurahashi, M.
Nihon Kyobu Geka Gakkai 28(8): 1229-1235
1980
ISSN/ISBN: 0369-4739 PMID: 6158539 Document Number: 160137
Serum gastrin, amylase, insulin and glucagon were studied during and after open heart surgery with cardiopulmonary bypass in 17 patients. The amount and the acidity of gastric juice increased gradually until 18 h after surgery. Gastrin level was directly proportional to the amount and the acidity of gastric juice. Decreasing levels of gastrin, amylase, insulin and glucagon occurred during cardiopulmonary bypass. The levels increased gradually after the stop of bypass, showing the highest level on the following day. Most of these levels were restored to normal within 5 days after surgery, with similar increase duration. There was a significant correlation between gastrin and amylase. A relationship was observed between gastrin and insulin. No evident correlation was found between gastrin and glucagon. Gastrin was not correlated with body surface area or perfusion time. No relationship was found to exist between gastrin and the hemodilution ratio or the lowest rectal temperature during bypass. An inverse relation was found between gastrin and mean arterial pressure during bypass, although the correlative coefficient was low. The increased secretion of gastrin after bypass apparently was produced as an inverse reaction to the decreased secretion during bypass.