Treatment of orthostatic hypotension induced by tricyclic antidepressants with yohimbine
Des Lauriers, A.; Widlocher, D.; Allilaire, J.F.; Lecrubier, Y.; Simon, P.
Annales de Medecine Interne 131(8): 508-509
1980
ISSN/ISBN: 0003-410X PMID: 7224460 Document Number: 158222
Following the observation that two patients with depression and essential orthostatic hypotension recovered from the latter affection after yohimbine administration, an open study was conducted to assess the activity of yohimbine in correcting orthostatic hypotension induced by tricyclic antidepressants. Results were conclusive in 10 of the 11 patients treated, and were confirmed in a further 12 cases during a double-blind study. Yohimbine appears to be the most effective treatment for orthostatic hypotension, either essential or induced by thymoanaleptic or neuroleptic therapy.