The treatment of orthostatic hypotension with metoclopramide
Laederach, K.; Weidmann, P.
Schweizerische Medizinische Wochenschrift 121(8): 264-269
1991
ISSN/ISBN: 0036-7672 PMID: 2011722 Document Number: 377243
The dopamine receptor antagonist metoclopramide (paspertin, primpéran, gastrosil, meclopran, gastro-timelets), used as monotherapy or in combination with an inhibitor of the cyclooxygenase enzyme, affords good results in orthostatic hypotension due to insufficiency of the sympathetic nervous system. The mechanism of action in these cases is unclear but is assumed to be elevation of vascular tone in the splanchnic vessels. A case is discussed which documents the effectiveness of metoclopramide therapy in orthostatic hypotension, even in absence of signs of autonomic dysfunction.