The morphology of the systemic anaphylactic reaction to bovine serum albumin and ferritin in rabbits. II. Electron microscopic findings
Jakubovský, J.; Brozman, M.
Ceskoslovenska Patologie 16(1): 5-11
1980
ISSN/ISBN: 1210-7875 PMID: 7379181 Document Number: 157992
The picture of rabbit systemic anaphylactic reaction to bovine serum albumin and ferritin is represented by tiny clusters of blood platelets and basophils in the microcirculation of different organs. Also present are signs of damage caused to the endothelium of different vessles, or to some of the blood cells as well as their subsequent breakdown in the liver and spleen. No signs of ferritin-antiferritin complex formation were found in the microcirculation of the affected animals. The platelet-ferritin relationship is seen as evidence of the degradation role of the platelets rather than of any specific antigen linkage to the surface of target cells. The above described systemic anaphylactic reaction was rather one of the whole organism than local reaction in the target organ even though many of the canges note there are probably alterations of a non-specific shock nature. No pronounced degranulation of basophils or other granulocytes was found despite the fact that a certain degree of degranulation could be observed. Morphological findings in model in vitro experiments cannot always be identified with findings observed in vivo during systemic anaphylactic reaction. Há Cs. Patol., 16, 1980, No. 1, p. 5-11.