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Changes in the sarcoplasmic proteins of skeletal muscles induced by experimental steroid myopathy

Takács, O.; Heiner, L.; Guba, F.

Acta Physiologica Academiae Scientiarum Hungaricae 55(2): 121-128

1980

ISSN/ISBN: 0001-6756
PMID: 7435205
Document Number: 157765
The protein content and the relative distribution of cell compartments was investigated after 14 days of dexamethasone treatment in rabbits. The cell fractions were analyzed by SDS-PAGE were opposite in the 2 types of muscle. Glucocorticoid treatment may cause a shift in the equilibrium of synthesis and degradation of myofibrillar and sarcoplasmic proteins. The different susceptibility of fast vs. slow muscles to steroid myopathy could be due to the activity-dependent regulatory mechanism of metabolic pathways.

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