Mice tolerant to nitrous oxide are also tolerant to alcohol

Koblin, D.D.; Deady, J.E.; Dong, D.E.; Eger, E.I.; Koblin, D.D; Deady, J.E; Dong, D.E; Eger, E.I

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Mice tolerant to nitrous oxide are also tolerant to alcohol

Koblin, D.D.; Deady, J.E.; Dong, D.E.; Eger, E.I.

Journal of Pharmacology and Experimental Therapeutics 213(2): 309-312

1980

ISSN/ISBN: 0022-3565

PMID: 7365690

Document Number: 157263

Mice exposed to 50% nitrous oxide for 3 weeks become tolerant to nitrous oxide. The nitrous oxide-tolerant animals are also tolerant to ethanol, as measured by a 40% decrease in ethanol-induced sleep times and 15% higher blood alcohol levels upon awakening compared to control mice raised in air. These results suggest a common mechanism for the development of tolerance to both alcohol and nitrous oxide.