Cross-mating of mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia: potencies of nitrous oxide in offspring
Koblin, D.D.; Eger, E.I.
Anesthesia and Analgesia 60(9): 646-648
1981
ISSN/ISBN: 0003-2999 PMID: 7196708 Document Number: 169653
To investigate the genetic bases of differences in N2O requirement in mice selectively bred for resistance (HI mice) or susceptibility (LO mice) to N2O anesthesia, the potency of N2O in offspring having 1 HI and 1 LO parent was measured. N2O ED50 (.+-. SD) in offspring having HI male and LO female parents or LO male and HI female parents were 1.53 .+-. 0.10 and 1.63 .+-. 0.14 atm, respectively. The N2O ED50 for offspring having 2 LO parents was 1.26 .+-. 0.09 atm, and for offspring having 2 HI parents, 1.96 .+-. 0.10 atm. The N2O ED50 for offspring produced by cross-mating HI and LO animals approximated the average values for their parents. No single gene determines dominance or recessiveness for N2O requirement in mice, and that the genetic control of resistance or susceptibility to N2O anesthesia probably involves many genes.