Immunoreactivity of ageing C57BL female mice rendered tolerant to the H-Y antigen
Skowron-Cendrzak, A.; Roman, A.; Holán, V.; Kubera, M.; Basta-Kaim, A.
Folia Biologica 40(6): 477-482
1994
ISSN/ISBN: 0015-5500 PMID: 7589705 Document Number: 432436
Transplantation tolerance to the H-Y antigen, induced in neonatal or young adult C57BL female mice, beneficially affected their immunoreactivity during the process of ageing. The tolerance acquired in 2-month-old females significantly increased their splenocyte graft-versus-host (GVH) reactivity and the production of interleukin-2 (IL-2) at the age of 18 months. The neonatally induced tolerance also resulted in a higher weight of the thymus and a significantly enhanced GVH reactivity of thymocytes in 18-month-old females compared to control mice of the same age.