The stability of adrenaline solutions; solutions of adrenaline tartrate
West, G.B.
Quarterly Journal of Pharmacy and Pharmacology 18: 267-279
1945
ISSN/ISBN: 0370-2979 PMID: 21005096 Document Number: 15609
1. The effects of variation of temperature, time and pH on solutions of adrenaline with tartaric acid have been studied in the presence and absence of sodium metabisulphite: 2. The results show two main routes of destruction, one due to oxygen and the other due to heat. As with the hydrochloride, pH is an important factor in influencing both rates of destruction. 3. It is suggested that the optimum conditions for stability and storage of solutions of adrenaline with tartaric acid when enclosed in well-filled ampoules are (a) an initial pH of approximately 3.6 and (b) the presence of 0.1 per cent. of sodium metabisulphite. 4. A solution of adrenaline acid tartrate with metabisulphite satisfies these conditions and can be sterilised by autoclaving (115° C. for thirty minutes), for the loss of activity would be negligible. 5. Formulae are suggested for a Solution of Adrenaline, using the present Pharmacopceial solution without sodium chloride and chlorbutol but containing metabisulphite, and for an Injection using solid adrenaline acid tartrate and metabisulphite.
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