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Toxicity and radioprotective properties of 3,4,5,6-tetrahydropyrimidine and 3,6-dihydropyrimidine derivatives

Il'iuchenko, T.I.; Frigidova, L.M.; Shadurskiĭ, K.S.; Lepekhin, V.P.; Ignatova, L.A.

Farmakologiia i Toksikologiia 43(1): 103-107

1980

ISSN/ISBN: 0014-8318
PMID: 7379985
Document Number: 155628
Acute toxicity and radioprotective properties of 16 derivatives of tetrahydro- and dihydropyrimidines were studied in experiments on mice. Hydroiodides of 4,6,6-trimethyl-3,R-2-methylthio-3,6-dihydropyrimidines were shown to be more toxic than respective hydroiodides of 4,6,6-trimethyl-3-R-2-methylthio-4-oxy-3,4,5,6-tetrahydropyrimidines. Four compounds exhibited moderate radioprotective properties.

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