Gd- allele distribution patterns in Azerbaijan. III. the identification of mutant forms of glucose-6-phosphate dehydrogenase
Shatskaia, T.L.; Krasnopol'skaia, K.D.; Zakharova, T.V.
Genetika 16(12): 2217-2225
1980
ISSN/ISBN: 0016-6758 PMID: 6453040 Document Number: 155466
In 28 families with G6PD deficiency living in 3 settlements of Shekii district of Azerbaijan 11 G6PD variants of II and III classes differing by kinetic properties were identified according WHO program. 9 of them are characterized with the same electrophoretic mobility. Comparison of G6PD spectra in two subpopulations and in a mixed group permits to make a conclusion about existence of common and rare G6PD alleles in examined population. They distribute by gene drift supported by natural selection. Among 7 samples of G6PD with normal and increased activity two new variants of IV class -- Nukha and Bash-Kungut -- were found.