Memory of Epstein-Barr virus-specific cytotoxic T cells in normal seropostive adults as revealed by an in vitro restimulation method
Tanaka, Y.; Sugamura, K.; Hinuma, Y.; Sato, H.; Okochi, K.
Journal of Immunology 125(4): 1426-1431
1980
ISSN/ISBN: 0022-1767 PMID: 6157733 Document Number: 154450
Peripheral blood lymphocytes (PBL) from healthy K-562 target cell lysis were derived from cultures from the seropositive and seronegative individuals, especially after the 1st and 2nd stimulations. Lysis of K-562 targets decreased after the 3rd and 4th restimulation. In 56 effector-target combinations, EBV-specific Tc induced always lysed autologous LCL cells more effectively than allogeneic LCL cells. These data and HLA-typing results suggested a possibility of the HLA-A or -B restriction of the EBV-specific Tc.