Detection of "alpha-type" inhibitors in the presence of low levels of specific influenza antibodies
Terzin, A.L.; Djurisić, S.; Vujkov, V.
Acta Virologica 23(2): 120-127
1979
ISSN/ISBN: 0001-723X PMID: 39434 Document Number: 152735
In native, heated or otherwise treated egg white and in sera of men and guinea pigs, haemagglutination inhibition titres were determined against three inhibitor-sensitive (IS) strains and one inhibitor-resistant (IR) variant on influenza A virus. A few human sera with no detectable antibody revealed high inhibition titres even against the IR variant. Human sera after treatment with trypsin and periodate revealed mostly a reduction or no change, and exceptionally an increase of their inhibition titre. The extent of these changes varied with different influenza virus strains and showed a positive correlation with the inhibitor content and no correlation with the antibody levels of the sera. The so-called "nonspecific" thermostable inhibitors possess a certain degree of specificity for different influenza virus strains.