Determination of bronopol in cosmetic products by HPLC with electrochemical detection

Scalia, S.; Simeoni, S.; Bousquet, E.

Die Pharmazie 56(4): 318-320

2001


ISSN/ISBN: 0031-7144
PMID: 11338672
Document Number: 1514
A procedure is described for the assay of bronopol in cosmetics by HPLC coupled with constant-potential amperometric detection. Samples were analysed on an Alltima C18 column with methanol-phosphate buffer as the eluent and detected at a porous graphite electrode set at a reduction potential of -0.9 V. The recovery of bronopol from different cosmetic matrices was between 96.4 and 98.8% and the precision of the method was better than 4.5% relative standard deviation.

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Determination of bronopol in cosmetic products by HPLC with electrochemical detection