Diseases produced by feline caliciviruses when administered to cats by aerosol or intranasal instillation
Ormerod, E.; McCandlish, I.A.; Jarrett, O.
Veterinary Record 104(4): 65-69
1979
ISSN/ISBN: 0042-4900 PMID: 433113 Document Number: 151127
SPF cats were infected by two feline calicivirus isolates of different plaque type, an extra-large plaque (ep) producer and a minute plaque (mp) producer. A comparison was made of the disease produced when these isolates were administered by either aerosol or direct instillation into the nose. With both isolates, aerosol infection produced lesions and gave rise to virus replication throughout the respiratory tract. The effects of nasal infection were more confined to the upper respiratory tract and oropharynx. By both routes of infection the disease produced by the mp virus was clinically and pathologically less severe than that produced by the "ep" virus.